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Among the GLP-1 RAs, evidence of CV benefit is strongest for liraglutide, favorable for semaglutide, and less certain for exenatide

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CagriSema's advantage is that semaglutide has a long clinical record, and amylin biology is conceptually complementary

While AOD-9604 is not FDA-approved as a prescription drug, it has received GRAS (Generally Recognized as Safe) status, indicating low toxicity and a good safety profile