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10.3390/biom11010002 Biomolecules 72 SimonsA.EyskensF.GlazemakersI.van WestD

The Four Amino Acid Substitutions Mechanism of Stability Four targeted amino acid substitutions D-Ala (position 2), Gln (position 8), Ala (position 15), and Leu (position 27) give CJC-1295 Without DAC dramatically improved resistance to DPP-IV proteolytic cleavage compared to native GRF (1-29), which has a half-life of under 10 minutes

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The excessive accumulation of ROS can activate intracellular oxidative stress response and damage proteins, nucleic acids, and lipids, finally resulting in the occurrence of ferroptosis (Tang et al., 2021)

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