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Therefore, it is important to consult a physician if heartburn comes with following symptoms: Episodes of heartburn occur more than twice a week Symptoms persist even after taking medicines Difficulty in swallowing Frequent nausea or vomiting Loss of appetite Weight loss Causes of heartburn In most cases, the main culprit for heartburn is acid reflux
2014 [77] Agrawal A, Scherrer JF, Grant JD, Sartor CE, Pergadia ML, Duncan AE, Madden PA, Haber JR, Jacob T, Bucholz KK, Xian H
LeeL.GerhardsteinD.WangA.BurkiN.1993Nicotine is responsible for airway irritation evoked by cigarette smoke inhalation in men.19551961 64