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The cuprizone model: regional heterogeneity of pathology

Indeed, EGR-1 was found to contribute to the pathogenesis of atherosclerosis [123], stenosed calcific valvular disease [124], and cardiac hypertrophy [125,126]

HCV infection-induced oxidative stress enhances fibrosis progression in chronic hepatitis C 94

[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

When nebulized individually, they can achieve local benefits while minimizing systemic side effects