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The elevated oxalate levels increase inflammation and fibrosis.[ref] Related article : Fatty liver disease NLRP3 inflammasome activation: The NLRP3 inflammasome is activated by increased ROS and calcium oxalate crystals

10.1038/s41380-018-0086-5 Mol

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It is located on human chromosome 2p16, and the protein encoded by the VRK2 gene is expressed in the human brain, testis, thymus and fetal liver [13]

These findings support biological delivery, but they do not establish that one form produces better clinical outcomes