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10.3390/ijms21072289 99 ChenS.WuD.RobinsonC

It consists of a single layer of specialized cells: enterocytes, goblet cells (produce mucins), Paneth cells (produce antimicrobial peptides and proteins), enteroendocrine cells, M cells and intestinal stem cells

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Methotrexate is a folic acid antagonist, and its use during the critical period of organogenesis (6-8 weeks postconception) is associated with multiple congenital anomalies collectively called methotrexate embryopathy or fetal aminopterin-methotrexate syndrome