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Supplementary Information Additional file 1: Additional material

The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

Choline contributes to the maintenance of normal liver function*

Studies have shown that transferring microbiota from adult male mice to immature females results in shifts in hormone levels (notably elevated testosterone), as well as changes in the metabolome and autoantibody production

In combination, hCG and hMG have been shown to increase sperm count and motility