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Its effect is gradual and appears most pronounced when combined with a caloric deficit and regular physical activity

Many people notice an improvement in energy and mental clarity within a few days of their first injection

This translates to stronger appetite suppression, more pronounced satiety signals, and greater reduction in food intake

A slowed metabolism and weight gain can occur for a variety of reasons, such as not eating enough calories, too much cortisol, high insulin levels, or thyroid problems

Until approval, retatrutide is not available through pharmaceutical channels except through clinical trial enrollment