Widely prescribed to womem Injecting: Started after the invention of hypodermic needle in 1853 Intravenous use takes 15-30 seconds Subcutaneous/intramuscular takes 3-5 minutes Snorting: Self-limiting method The more snorted, the less absorption due to constriction of capillaries in the nose Destructive to nasal passages COCAINE: Routes of Administration Mucosal & contact absorption Can be absorbed through mucosal tissue in nose, mouth, rectum & vagina Delivery method is also used for dental work, minor surgeries Smoking: First introduced in 1914, but high temperature was needed to keep cocaine cigarettes going Mid-1970s, cocaine hydrochloride was chemically altered into freebase Fastest form to reach brain Highly addictive COCAINE: Physical and Mental Effects Metabolism: Quickly metabolized and disappears faster than methamphetamine Medical Use: Only naturally occurring local anesthetic Used to numb nasal passages, eyes, throat, and chronic sores Neurochemistry & Central Nervous System Forces relase of norepinephrine, epinephrine and dopamine Blocks re-absorption so more intense stimulation Blocks 60-70% of dopamine reuptake Too much dopamine can over stimulate brains fright center causing paranoia
Les points cls en un coup d'il Marlboro Gold : douceur lgre, tirage initial plus doux Winston Blue : audace subtile, saveur initiale plus riche Ces premires impressions suggrent dj que l'arrire-got aura des personnalits distinctes
This enhancement broadens the pathways linked to attitudes, thereby offering new frameworks for understanding vaping behavior
Pouvanm naich strnok shlaste s ukladanm sborov cookie na vaom potai / zariaden
If Earth and Wood are affected, often metal is as well
