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The 2022 publication of revised consensus diagnostic criteria for multiple system atrophy and the emergence of promising biomarkers provides a thorough diagnostic framework that now enables the diagnosis of numerous acquired causes of SLOCA, including autoimmune disorders and neurodegenerative diseases

Sermorelin improvements in sleep depth and morning recovery often appear within the first few weeks

Given this clinical history and the mode of inheritance of clEDS, a diagnosis of clEDS is likely, though unproven

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This hormone, though needed in emergency situations, is destructive in excess: it destroys muscles, promotes fat storage, and disrupts sleep