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Ethics declarations Ethics approval and consent to participate All animal experimental procedures were conducted in strict accordance with relevant laws and regulations and approved by the Institutional Animal Care and Use Committee (IACUC) of Sun Yat-Sen University (Reference: SYSU-IACUC- 2023002545)

The specific combination of phytochemicals encapsulated within NPs, along with their size and shape characteristics, determines their overall impact on different regulatory pathways involved in diabetes management ( Figure 3 )

Novo Nordisk investigated cagrilintide in monotherapy and combination trials, notably the CagriSema program

While ALT is present only in cytoplasm, AST is present in both cytoplasm and mitochondria