ProHealth BPC-157 is a dietary supplement, not an FDA-approved drug
Data availability Atomic coordinates and structure factors for the crystal structures of the TRF1 TRFH domain in complex with the compounds discussed herein have been deposited in the Protein Data Bank (www.wwpdb.org) and can be accessed using the PDB accession numbers provided in Supplementary Table 3
BPC-157 protects somatosensory neurons, promotes peripheral nerve regeneration after transection, counteracts the otherwise progressing course after traumatic brain injury, and in rat spinal cord compression models with tail paralysis, addresses axonal and neuronal necrosis, demyelination, and cyst formation while rescuing tail function
It was pointed out that this behavior was in line with the previously reported data for poly (D-glutamic acid) in random coil, helical, and a mixture of helix and coil forms (Muroga et al., 1988)
PMCID: PMC5687246