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While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

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Studies show improved outcomes in models of osteoarthritis and joint damage, likely mediated through growth factor upregulation and anti-inflammatory pathways

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Optimal results require 8-12 weeks of consistent use combined with appropriate nutrition and exercise