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Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects

Lanthanum-based nanoparticles (La 2 O 3 NPs) offer therapeutic advantages in glioblastoma treatment ( 2 O 3 NPs enhance apoptosis, DNA double-strand breaks, and autophagy by molecular mechanisms involving ROS/-H2AX signaling and Bcl-2 expression

However, it has a high potential for side effects, including significant weight gain

BioSpace / Novo Nordisk corporate release (2026) 9

Additionally, by stabilizing microtubules, paclitaxel impairs the axonal transport of mitochondria and other essential molecules along neurons (Shemesh and Spira, 2009)