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Accumulating evidence suggests that the regulation of ferroptosis can change the level of OS in cardiomyocytes or vascular cells, resulting in cardiomyocyte injury, cardiac hypertrophy and HF through the interaction between ROS with ERS (Kamoshita et al., 2014

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Additionally, serum levels of iNOS and interleukin 6 (IL-6) were significantly reduced in the group receiving the supplement (108)

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6.1 Macrophage recruitment mechanisms initiated by ferroptotic cells Ferroptosis occurs in various disease states, with macrophages responsible for ferroptotic cell clearance