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1 Introduction Neurodegenerative diseases such as Alzheimers disease (AD), Parkinsons disease (PD), and multiple sclerosis (MS) are characterized by progressive nerve damage and chronic inflammation

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Functionally, synaptic mitochondria are extrapolated to have a 35%40% decrease in ATP synthesis based on the reported decrease in complex I activity [102], as well as elevated markers of oxidative damage [103]