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No Improvement from At-Home Care : If home remedies and over-the-counter treatments (such as moisturising, exfoliation, or sun protection) do not improve the pigmentation, a more targeted treatment plan may be required

The accumulation of ROS leads to the opening of the mitochondrial permeability transition pore (mPTP) and dissipation of the mitochondrial membrane potential, resulting in a surge of ROS in a phenomenon termed ROS-induced ROS release (RIRR) [46]