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Using weed alone, without tobacco, lowers these chances

Nicotine is a chemical made by tobacco leaves that looks and acts like a neurotransmitter (a normal chemical signal in the brain) called acetylcholine

References & Further Reading The Chemical Constituents in Cigarettes & Cigarette Smoke J Fowles et al The Chemistry & Toxicology of Cigarette Smoke US Department of Health & Human Services Student Guide to Chemicals in Cigarette Smoke SBCTC Application of Toxicological Risk Assessment to the Chemical Constituents of Cigarette Smoke J Fowles, E Dybing.

Gori, has a controversial history, first as a former NCI deputy director and later as a tobacco industry consultant

[59] [60] This has contributed to the development and public-health discussion of non-combustible nicotine and tobacco products, such as electronic cigarettes, heated tobacco products, and smokeless tobacco, which are being promoted as possible alternatives for adults who would otherwise continue to smoke