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MMPs are zinc-dependent enzymes that break down extracellular matrix components like collagen and elastin

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Here, most effects were found in pathways citric acid cycle and respiratory electron transport (q-value: 3.5 * 10 10 , 63 DEGs out of 171 genes, 76.2% downregulated), glucose metabolism (q-value: 9.9 * 10 9 , 36 DEGs out of 77 genes, 80.5% downregulated) and metabolism of lipids and lipoproteins (q-value: 2.9 * 10 6 , 165 DEGs out of 728 genes, 55.2% downregulated)