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This exercise-responsive pattern led researchers to propose MOTS-c as a mitokine, a signaling molecule released by the mitochondria during physical exertion that mediates some of the systemic benefits of exercise

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Pharmacologic measures include NSAIDs, local glucocorticoid injections, and experimental chondroprotective drugs (e.g., chondroitin sulfate and glucosamine)

hypothalamus and brain stem nuclei), as well as regions involved in synaptic plasticity, memory, reward functions and emotional responses (Figure)