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The typical outcome measure used by researchers is the Sciatic Function Index that assesses hind limb motor function based on toe to toe and toe to heel distance

Proof-of-concept randomized controlled study of cognition effects of the proprietary extract Sceletium tortuosum (Zembrin) targeting phosphodiesterase-4 in cognitively healthy subjects: Implications for Alzheimers dementia

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Yes, you can apply the cream to different areas (e.g., neck, knees, wrists) following the application instructions for each zone