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An inactive mutant form of GPX4 (the heterozygote of Gpx4_U46S) produces reduced litter size resulting from heterozygous reproduction and impaired sperm fertilization of oocytes in vitro [26]

Furthermore, researchers discovered that osmundacetone (OSC), a bioactive phenolic compound derived from Phellinus igniarius, exhibited regulatory effects on the immune microenvironment, as confirmed by downregulation of GLUD1 expression upon OSC treatment [211]

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Glutathione IV therapy is a medical treatment where glutathione is given directly into your vein through an IV drip

Reintroduction of SIRT1 restored xCT and NRF2 expression and suppressed TFRC levels (Figure 3D)