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Interestingly, these neuroprotective features have also been shown in humans, where post-menopausal women taking HRT, had fewer and smaller damaged areas after an ischemic event comparing to controls (non-HRT) ( Estrogens and Estrogen-Like Molecules in Neurogenesis and Gliogenesis Neurogenic Niches: Adult Neural Stem/Progenitor Cells (NSPCs) Stem cells are able to undergo proliferative divisions that produce additional stem cells with the same properties, and divisions that produce daughter cells that differentiate into multiple cell types ( Postnatal neurogenesis has been well demonstrated in two specific regions of the mammalian brain: the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus ( In the SVZ, type B cellsadult multipotent NSPCs are located below ependymal and ependymal-like cells, which line the walls of the lateral ventricles ( In the SGZ, radial glia-like or type 1 cellsadult multipotent NSPCs also exhibit a multistep differentiation process as described for the SVZ niche, beginning with the expansion of type 2a cells (transient amplifying progenitor cells) (Seri et al., 2001