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For instance, high doses of antioxidants like beta-carotene or vitamin E may not always be beneficial and could even exacerbate oxidative damage, particularly before exposure to harmful agents like radiation or cigarette smoke (51)

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They also confirmed that toxic oligomers were identified intracellularly in -cells from humans with type II diabetes

We express our gratitude to Pengfei Gong, Ruipei Ouyang, and Yongjie Shi from Jiangsu Province Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, China Pharmaceutical University , for helping revise the manuscript

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