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In hippocampal tissues, mRNA expression studies at 1 h and 24 h, and strongly elevated ( Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, Nos3, Nos1 ) and decreased ( Nos2, Nfkb ) gene expression ( Mapk1 not activated) also support BPC 157 beneficial effect on brain lesions, given in reperfusion in stroke-rats [30]

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For one, it makes a robust clinical trial logistically tricky, said Christopher Milne, past director of research at the Tufts Center for the Study of Drug Development

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