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Because it is a protein, a large amount of ingested glutathione is broken down by the gut and eliminated before reaching the cells

However, this study was undertaken in 13 day old mice, as without IR they were not viable, and thus, results are not conclusive [159]

What dosing protocol was used in the landmark FOXO4-DRI mouse study

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Comprehensive results demonstrate that polystyrene nanoparticles (PS-NPs) disrupt glucose and lipid metabolism, induce insulin resistance (IR) resulting in elevated plasma glucose levels, and promote hepatic glycogen synthesis (64)