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Apart from exacerbating local inflammation, TNF- can activate the NF-KB and MAPK signaling pathways, increasing cellular susceptibility to oxidative stress and weakening GPX4 and other antioxidant enzymes, thereby promoting further accumulation of lipid peroxidation byproducts and markedly elevating ferroptosis risk (119)

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Thyroid hormone receptor activation affects the expression of a wide range of genes, including metabolism and energy production.[ref] Recent research shows that mast cells have thyroid-stimulating hormone (TSH) receptors on their cell membranes

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Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-1: potential role in idiopathic pulmonary fibrosis