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In experimental diabetes bilirubin is implicated in the reduction of oxidative stress which augments the bioavailability of nitric oxide (NO) needed for the integrity of endothelial cells (46)

In each generation, three libraries were generated at different levels of mutagenesis with the following primers: forward, 5- GGAGGAGGCTCTGGTGGAGGCGGTAGCGGAGGCGGAGGGTCGGCTAGCCATATG-3

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