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These may include: Fatigue Brain fog Memory loss Neurological problems Heart palpitations Pale skin Muscle weakness Mood changes Appetite loss Constipation Infertility Side Effects of Vitamin B12 While the recommended daily amount of vitamin B12 for adults is 2.4 micrograms, higher doses have been found to be safe

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Weight of evidence: Overall evidence is ModerateLow : encouraging signal from a historical cross-over trial but limited by small samples and lack of biomarker data