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Moreover, PTEN loss, a common event in CRPC, enhances dependency on p110-mediated LPA (unspecified species) signaling in a mouse model of prostate tumorigenesis (69), raising the possibility that PTEN deficiency might indirectly augment the LPA pathway, though direct transcriptional regulation has not been demonstrated

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Glutamine is the most abundant free amino acid in human tissues and serves as a key component in protein synthesis, intestinal integrity, and immune system metabolism