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10.1523/JNEUROSCI.2198-11.2011 J

Other contributors may include mast-cell activation, allergy, chronic inflammation, medication effects or reduced intracellular breakdown by HNMT

The figure below shows the reaction through which ascorbic acid can stabilize or quench 2 free radicals

The forward signal occur when Eph/ephrin signal transduce into receptor-binding cell and the reverse signal when the ligand-receptor interaction leads to transduction into the ligand-expressing cell, reviewed in [155]