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Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes (Caballero et al., 2007)

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Therapeutically administered AMPs represent a new direction in non-antibiotic periodontal management working with the body's own defenses rather than against the microbiome broadly