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In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]

Abdominal visceral fat accumulation measured by computed tomography associated with an increased risk of gallstone disease

Yu, W., et al

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If the molecule is broken back down into its three component amino acids, it loses its "master antioxidant" status and becomes just another protein source