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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision

Yes no known interactions

This increase was discussed in thread below

Some patients may struggle to absorb enough B12 from diet or oral supplements, especially those with conditions like pernicious anemia, gastrointestinal disorders, or those who have undergone certain surgeries

weekly, biweekly, or monthly injections are common depending on deficiency and goals