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This is likely due to the rectal absorption of caffeine and enhanced detoxification

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Springer Berlin Heidelberg 397 (2024) Mishra G, Awasthi R, Mishra SK, Singh AK, Tiwari AK, Singh SK et al (2024) Development of epigallocatechin and ascorbic acid dual delivery transferosomes for managing Alzheimers disease: in vitro and in vivo studies