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Neuroendocrine Regulation Hypophysiotropic Activity Thymulin acts as a hypophysiotropic peptide, regulating pituitary hormone release in dispersed rat pituitary cell studies: [7] Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release Growth hormone (GH) and prolactin (PRL) secretion Thyrotropin (TSH) release Adrenocorticotropic hormone (ACTH) secretion via cAMP and cGMP accumulation Thymulin also modulates GnRH stimulatory activity on gonadotropin release and influences gonadotropin-induced ovarian and testicular steroidogenesis