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By selectively inhibiting NNMT an enzyme central to energy regulation and fat metabolism this compound has demonstrated, in preclinical studies, the capacity to elevate intracellular NAD and SAM levels, suppress lipid accumulation in adipocytes, and reduce white adipose tissue mass in diet-induced obese mouse models

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The challenge during semaglutide use involves reduced appetite making it harder to consume adequate amounts of any food, including b12-rich options

If you are self-supplementing with high doses, discuss this with your GP to ensure it remains appropriate and safe for your individual circumstances