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Some of the nuclear enzymes that require Mg 2+ for activity are DNA repair endonucleases involved in nucleotide excision repair (NER) and mismatch repair (MMR), topoisomerase II, and RNase H

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The structural and functional diversity of the TME, shaped by irregular vasculature and variable oxygenation 7,8 , can lead to uneven chemotherapy exposure, resulting in suboptimal outcomes or even chemotherapeutic hormesis, wherein low doses of chemotherapy inadvertently promote tumor growth

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Reported Side Effects by Dose Level Most gastrointestinal side effects were mild to moderate and occurred primarily during dose escalation