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Rosacea: Diagnosis, Treatment, and Steps to Take

suppl 3 S434-S442

Importantly, 5/-reduction is irreversible, with the stereochemistry of this reduction playing an important role in regulating the biological activity of androgens (Section 4.3.2) [93]

For instance, NRF2 inhibitors, such as Brusatol and Brucein D, promote ubiquitination and proteasomal degradation of NRF2, enhancing chemosensitivity in cancers like AML, endometrial cancer, and pancreatic ductal adenocarcinoma