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Histology and biochemistry assessment was carried out immediately after sacrifice after paracetamol challenge at 25 min (general seizure initiation), 3 h (at the time of maximal convulsion, used as the point of therapeutic application of BPC 157 regimens) and at 24 h post-paracetamol

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ATF4 then attaches to amino acid response elements (AARE) in gene promoters, regulating transcription of genes involved in amino acid metabolism and stress response (21)