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Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

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According to Hartenstein and Giangrande (2018), astrocytes and oligodendrocytes are neuroectodermally derived lineages that are absent in prebilaterian animals (such as Cnidaria and Ctenophora) and in basal branches of the Bilateria

That is a meaningful fraction of a dose