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mTOR regulates the proliferation and activation of B lymphocytes B cells participate in the pathogenesis of RA by producing autoantibodies, proinflammatory cytokines, and chemokines, acting as efficient antigen-presenting cells and regulating T cell activation and differentiation [69, 70]

Table 3 shows the significant effects of chitosan and its derivatives-based, synthetically-made nano-formulations

Resultantly, the protein could be misfolded or subjected to erratic post-translational modification, ultimately being more susceptible to proteolysis and other forms of degradation in the RBC (88)

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