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"As far as WHO is aware, no rigorous, peer-reviewed studies have been conducted showing that the electronic cigarette is a safe and effective nicotine replacement therapy," the World Health Organization wrote in 2008

Int J Environ Res Public Health 12:1428514300 Zheng L, Kuo C, Fadrowski J et al (2014) Arsenic and chronic kidney disease: a systematic review

[6] [7] Psychoactive substances have been used medicinally and to alter consciousness

The start of the GFN conference saw the European premiere of a documentary A Billion Lives which is the WHO estimate of tobacco-related deaths by 2100

Clearly there's a market for cigarette alternatives