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This review was compiled from major scientific databases, including PubMed, Web of Science, Scopus, and Google Scholar

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Compared to GHRH analogues (sermorelin, CJC-1295 with or without DAC, tesamorelin): different mechanism (GHS-R1a Gq/Gs vs GHRHR Gs), systematically documented supra-additive synergy in co-administration

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Poor-quality peptides may contain contaminants, incorrect concentrations, or degraded product that could increase side effect risks or reduce efficacy