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d , Representative images from immunohistochemical staining of Smurf1, p-PDK1 (S241), p-Akt (T308), PDK1 neddylation (K163) in tumors and matched adjacent tissue

Relative quantitative evaluation was performed by the comparative DDCt method

Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: altered biogenesis and mitochondrial metabolism of H 2 S lead to H 2 S deficiency in calcific aortic valve disease

10.1016/j.neuint.2017.01.004 47 HamanoM.TomonagaS.OsakiY.OdaH.KatoH.FuruyaS

However, only 41.8% stayed on treatment at 6 months 109 , in line with the available literature reporting disappointingly low adherence to liraglutide for obesity management and raising concerns about its role in the lifelong challenge of BW control and weight-related complications 110