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To place alternatively bound SA in UGT74F2 T15S , SA was manually placed in the binding site with 2-hydroxyl group in the small lobe in the ligand electron density and the benzene ring placed into the planar density

Concurrently, the expression levels of heme oxygenase-1 (HO-1) and kelch-like ECH-associated protein 1 (KEAP1) are also significantly elevated [17]

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This suggests that even moderate increases in vitamin B12 levels can reduce the likelihood of testosterone deficiency in men with infertility

Higher doses were associated with increased gastrointestinal adverse events , though most were classified as mild to moderate in severity