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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

This work was supported by the Basic Scientific Research Operating Expenses Program for Inner Mongolia Autonomous Region Universities (grant number BR231404)

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It is essential for detoxification, immune balance, and protection against oxidative stress