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PLoS ONE 7 , e38322 (2012)

B12 Deficiency and Dermatological Symptoms Patients with a vitamin B12 deficiency may notice dermatological symptoms such as hyperpigmentation, vitiligo, or dry, irritated skin

This is a general pharmacokinetic principle based on the protein stability characteristics of each formulation

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The ligands for PD-1, namely PD-L1 and PD-L2 (members of the B7 family), are expressed on tumor cells and MDSCs [107], tumor-associated macrophages (TAMs), and M2 macrophages [22]