What the clinical trials actually found Six randomized, double-blind, placebo-controlled trials involving over 900 participants have evaluated AOD 9604 in humans
Based on the in vivo experiment in the ICV-STZ rat model of AD, modulation of the PI3K/Akt/GSK3 signaling pathway could diminish oxidative stress, neuro-inflammation, and apoptosis, Moreover, amyloid plaque number and phosphorylated tau expression were marked decrement ( 142 to adult rats could disrupt the reduction-oxidation (redox) balance and significantly affect neurotransmitter dysfunction, synaptic dysfunction, and cognitive dysfunction (Yamini et al., 2022)
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148,149 OGG1 has eight Cys residues and is sensitive to oxidative stress induced by various oxidants, such as cadmium
