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[DOI] [PubMed] [Google Scholar] 5.Wess G, Unterer S, Haller M

A program without a target cannot be optimized through medicinal chemistry, cannot generate target-engagement biomarkers and cannot be de-risked for off-target liabilities

observed that APS stimulate KCs by decreasing the amounts of recombinant autophagy-related proteins (ATGs), family members (ATG7, ATG12, and ATG6), and protein II light chain 3 (LC3II), resulting in a decrease in CD68-positive KCs (Hamid et al., 2017b)

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FOXKs promote Wnt/-catenin signaling by translocating DVL into the nucleus